Optimal Dosing of Breast Cancer Chemotherapy Using Robust MPC Based on Linear Matrix Inequalities
Keywords:Robust model predictive control, breast cancer chemotherapy, model-patient mismatch, linear matrix inequalities
In this paper, we consider an application of robust model predictive control to optimal dosing of breast cancer chemotherapy. The model-patient mismatch is handled by computing an ellipsoidal invariant set containing the measured patient's states at each sampling time. An optimal dose of chemotherapeutic agent is obtained by solving a convex optimization problem subject to linear matrix inequalities. In the case study of simulated patients, the results show that the tumor volume can be reduced to a specified target with up to 30% model-patient mismatch. Moreover, the robust model predictive control algorithm can achieve better treatment results as compared with the nonlinear model predictive control algorithm while the on-line computational time is significantly reduced.
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