Mixing-Performance Evaluation of a Multiple Dilution Microfluidic Chip for a Human Serum Dilution Process

Authors

  • Therdthai Thienthong King Mongkut’s University of Technology North Bangkok
  • Ekachai Juntasaro King Mongkut’s University of Technology North Bangkok
  • Witsaroot Sripumkhai National Science and Technology Development Agency, Thailand
  • Nongluck Houngkamhang King Mongkut’s Institute of Technology Ladkrabang
  • Mayuree Chanasakulniyom Mahidol University
  • Numfon Khemthongcharoen Mahidol University
  • Pattaraluck Pattamang National Science and Technology Development Agency, Thailand
  • Nithi Atthi National Science and Technology Development Agency, Thailand
  • Chamras Promptmas Mahidol University
  • Panapat Uawithya Mahidol University
  • Wutthinan Jeamsaksiri National Science and Technology Development Agency, Thailand

DOI:

https://doi.org/10.4186/ej.2021.25.9.67

Keywords:

microfluidics, dilution, mixing flow, mixing index, human serum

Abstract

This paper is aimed to propose a numerically designed multiple dilution microfluidic chip that can simultaneously deliver several serum dilutions in parallel. The passive mixing scheme is selected for dilution and achieved by the serpentine mixing channel in which Dean vortices are induced to increase the contact area and time for better diffusion. The mixing performance at the exit of this dilution chip is numerically evaluated using five commonly-used mixing indices with the goal that the homogeneity of the mixture over the exit cross-sectional area of the mixing channel must be greater than 93.319% to fulfill the six-sigma quality control.

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Author Biographies

Therdthai Thienthong

Mechanical Engineering Simulation and Design Group, The Sirindhorn International Thai-German Graduate School of Engineering (TGGS), King Mongkut’s University of Technology North Bangkok, Bangkok 10800, Thailand

Ekachai Juntasaro

Mechanical Engineering Simulation and Design Group, The Sirindhorn International Thai-German Graduate School of Engineering (TGGS), King Mongkut’s University of Technology North Bangkok, Bangkok 10800, Thailand

Witsaroot Sripumkhai

Thai Microelectronics Center, National Electronics and Computer Technology Center, National Science and Technology Development Agency, Chachoengsao 24000, Thailand

Nongluck Houngkamhang

College of Materials Innovation and Technology, King Mongkut’s Institute of Technology Ladkrabang, Bangkok 10520, Thailand

Mayuree Chanasakulniyom

Department of Clinical Chemistry, Faculty of Medical Technology, Mahidol University, Nakhon Pathom 73170, Thailand

Numfon Khemthongcharoen

Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom 73170, Thailand

Pattaraluck Pattamang

Thai Microelectronics Center, National Electronics and Computer Technology Center, National Science and Technology Development Agency, Chachoengsao 24000, Thailand

Nithi Atthi

Thai Microelectronics Center, National Electronics and Computer Technology Center, National Science and Technology Development Agency, Chachoengsao 24000, Thailand

Chamras Promptmas

Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Nakhon Pathom 73170, Thailand

Panapat Uawithya

Department of Physiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand

Wutthinan Jeamsaksiri

Thai Microelectronics Center, National Electronics and Computer Technology Center, National Science and Technology Development Agency, Chachoengsao 24000, Thailand

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Published In
Vol 25 No 9, Sep 30, 2021
How to Cite
[1]
T. Thienthong, “Mixing-Performance Evaluation of a Multiple Dilution Microfluidic Chip for a Human Serum Dilution Process ”, Eng. J., vol. 25, no. 9, pp. 67-87, Sep. 2021.

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